Compounds for treating proliferative disorders

A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following formulas:

• or a tautomer, pharmaceutically acceptable salt, thereof, wherein:
• Z1 are Z2 are independently O, S, Se, Te, Po, NR13, PR13, AsR13, SbR13 or BiR13;
• Z3 and Z4 are independently O, S, Se, Te, Po, N(R13)m, P(R13)m, As(R13)m, Sb(R13)m, or Bi(R13)m;
• provided that when one of Z1 or Z2 is S and the other is O or S, then Z3 and Z4 are not O or S, provided that when Z1 and Z2 are both O, then Z3 and Z4 are not both S and provided that Z1, Z2, Z3 and Z4 are not all O or S;
• Z5 are Z6 are independently O, Se, Te, Po, NR13, PR13, AsR13, SbR13 or BiR13, provided that Z5 and Z6 are not both O;
• Y is a covalent bond, an optionally substituted C1-C6 alkylene group,
• Y″ is a covalent bond, or a substituted or unsubstituted C1-C6 alkylene group;
• R″1 and R″2 are independently an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, or an optionally substituted heteroaryl;
• R3 and R4 are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl;
• R5 and R6 are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl;
• R7 and R8 are each independently —H or an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, or R7 is —H and R8 is an optionally substituted aryl or an optionally substituted heteroaryl;
• R13 for each occurrence is, independently, —H, —OR17, —NR19R20, —C(O)R17, —C(O)OR17, —OC(O)R17, —C(O)NR19R20, —NR18C(O)R17, —OP(O)(OR17)2, —SP(O)(OR17)2, —SR17, —S(O)pR17, —OS(O)pR17, —S(O)pOR17, —NR18S(O)pR17, or —S(O)pNR19R20, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R17 and R18, for each occurrence, are, independently, —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R19 and R20, for each occurrence, are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• or R19 and R20, taken together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl or an optionally substituted heteroaryl;
• m is 0 or 1;
• p is 1 or 2;
• q is 1 or 2;
• and
• with the provisos that
• when Z1 and Z2 are both O or both S and Z3 and Z4 are both N(R13)m, then Y taken together with both >C═Z3 and >C═Z4 does not form not an optionally substituted pyrimidine ring or an optionally substituted pyrazole ring;
• when Z3 and Z4 are both O, Z1 and Z2 are both NH, and Y is a covalent bond, or a substituted or unsubstituted C1-C6 alkylene group, then R3, R4, R5, and R6 can not all be —H;
• when Z1 and Z2 are both O and Z3 and Z4 are both NH, and Y is a covalent bond, or a substituted or unsubstituted C1-C6 alkylene group, then R3, R4, R5, and R6 are not all —H.