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US 8,093,287 B2Granted
Inhibitors of matrix metalloproteinases
AssigneesUniversity of Notre Dame du Lac, Wayne State University
InventorsMijoon Lee, Masahiro Ikejiri, Mayland Chang, Rafael Fridman, Shahriar Mobashery
Life of this patent
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Abstract
The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat conditions and diseases associated therewith.
Claims20
A compound of Formula (30):
- wherein
- R3 and R4 are each independently H, OH, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, aryl, heteroaryl, carboxy, cyano, nitro, halo, trifluoromethyl, trifluoromethoxy, SR5, SO2N(R5)2, NR5R5, or COOR5;
- each R5 is independently H, (C1-C6)alkyl, (C1-C6)alkanoyl, (C6-C10)aroyl, aryl, aryl(C1-C6)alkyl, heteroaryl, heteroaryl(C1-C6)alkyl, or a nitrogen protecting group;
- any alkyl, amino, aryl, or heteroaryl is optionally substituted with 1 to about 5 (C1-C6)alkyl, (C1-C6)alkoxy, aryl, heteroaryl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, nitro, halo, amino, or hydroxy groups;
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.