Optimised micro-organism strains for NADPH-consuming biosynthetic pathways
AssigneeMetabolic Explorer
InventorsGwénaëlle Bestel-Corre, Cédric Boisart, Michel Chateau, Benjamin Gonzalez, Philippe Soucaille, Rainer Figge, Olivier Zink
Life of this patent
Estimating the term…
Abstract
The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in NADPH-consuming biotransformation methods. Said strains are characterized in that one or more NADPH-oxidizing activities are limited.
Claims13
A strain of a micro-organism comprising NADPH-oxidizing activity that is reduced by a deletion of at least one gene coding for an enzyme selected from the group consisting of a quinone oxidoreductase and a soluble transhydrogenase, and wherein said strain has undergone a modification that enhances at least one NADP+-reducing enzyme activity of said strain by a deletion of at least one gene coding for an enzyme selected from the group consisting of a phosphoglucose isomerase and a phosphofructokinase.
Dependencies are inferred from the claim text.