Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
AssigneeImmunoGen, Inc.
InventorsRita M. Steeves, Ravi V. J. Chari, Walter A. Blättler
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Abstract
The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
Claims143
A method for targeting maytansinoids to a selected cell population in vivo, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population,
- wherein the cell-binding agent is an antibody, a single chain antibody or an antibody fragment that specifically bind to a target cell, wherein at least a constant region of the antibody, single chain antibody or antibody fragment comprises a human antibody sequence, and, provided that the cell-binding agent is not an anti-erbB antibody.
A method of eliminating cells in vivo, the method comprising contacting the cells in vivo with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to the cells,
- wherein the cell-binding agent is an antibody, a single chain antibody or an antibody fragment that specifically binds to a target cell, wherein at least a constant region of the antibody, single chain antibody or antibody fragment comprises a human antibody sequence, and provided that the cell-binding agent is not an anti-erbB antibody.
A method of treatment of afflictions selected from the group consisting of tumors, autoimmune diseases, graft rejections, graft versus host disease, viral infections, and parasite infections, the method comprising administering to a subject in need of treatment an effective amount of a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds diseased or infected cells of the affliction,
- wherein the cell-binding agent is an antibody, a single chain antibody or an antibody fragment that specifically binds to diseased or infected cells of the affliction, wherein at least a constant region of the antibody, single chain antibody or antibody fragment comprises a human antibody sequence, and provided that the cell-binding agent is not an anti-erbB antibody.
Dependencies are inferred from the claim text.