Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

A compound having the following structure (I):

• or a stereoisomer or pharmaceutically acceptable salt thereof,
• wherein:
• A is pyridyl, phenyl or quinolinyl substituted with 0-5 R4;
• R1a is H, halogen, C1-4alkyl, alkoxy or trifluoromethyl;
• R1b and R1c are the same or different and are independently H, halogen, hydroxy, haloC1-4alkyl, —C1-6alkyl-(R5)p, —O—C1-6alkyl-(R5)p, —C1-6alkyl-O—C1-6alkyl-(R5)p, —NR7—C1-6alkyl-(R5)p, or —S(O)m—C1-6alkyl-(R5)p;
• R1d is Cl, F, methyl, CF3 or cyano;
• R2 is —C1-4alkyl-(R5)p;
• R2a is phenyl substituted with 0-4 R3, heteroaryl substituted with 0-4 R3, C1-6alkyl substituted with 0-4 R3, aryl-C1-4alkyl substituted with 0-4 R3, or heteroaryl-C1-4alkyl substituted with 0-4 R3, wherein R2a is acyclic or comprises phenyl, pyridyl or quinolinyl;
• R3 at each occurrence is independently halogen, cyano, halo-C1-4alkyl, R5, —C1-6alkyl-(R5)p, —C1-6alkyl-O—C1-6alkyl-(R5)p, —O—C1-6alkyl-(R5)p, —NR7—C1-6alkyl-(R5)p, —S(O)m—C1-6alkyl-(R5)p, —O—C1-6alkyl-NR7—C1-6alkyl-(R5)p, heterocycle-(R5)p, wherein R3 is acyclic or comprises pyridyl or quinolinyl;
• R4 at each occurrence is independently halogen, C1-6alkyl, haloC1-4alkyl, C1-6alkoxy, hydroxy, cyano, thioC1-6alkyl, or —C(O)NR7R8, wherein R4 is acyclic;
• R5 at each occurrence is independently H, hydroxy, —OC(O)—C1-6alkyl, —OC(O)O—C1-6alkyl, —OC(O)—C1-6alkyl-NR7R8, —COOR6, —C(O)NR7R8, —NR7C(O)NR7R8, —S(O)2NR9R9, —S(O)m—C1-4alkyl, —NR7R8, C1-6alkoxy, —O-heterocycle, or heterocycle wherein said heterocycle and said —O-heterocycle are substituted with 0-4 groups selected from halogen, C1-6alkyl, C1-4-haloalkyl, hydroxy, oxo, thio, —NH2, —S(O)2C1-4alkyl and —COOH, wherein R5 is acyclic or comprises pyridyl or quinolinyl;
• R6 at each occurrence is independently H, C1-4alkyl, C1-4alkyl-O—C(O)—C1-6alkyl, or C1-4alkyl-O—C(O)—O—C1-6alkyl;
• R7 at each occurrence is independently H, C1-4alkyl, hydroxy, or heterocycle where said heterocycle is substituted with 0-4 groups selected from halogen, C1-6alkyl, hydroxy, keto, —NH2 and —COOH, wherein R7 is acyclic or comprises phenyl, pyridyl or quinooinyl;
• R8 at each occurrence is independently H, C1-4alkyl, haloC1-4alkyl, —C(O)—C1-4alkyl, —C(O)-haloC1-4alkyl, —S(O)m-haloC1-4alkyl or —S(O)m—C1-4alkyl;
• R9 at each occurrence is independently H, C1-4alkyl, or —C(O)C1-4alkyl;
• m is 0-2;
• and
• p at each occurrence is independently 1-3.