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US 8,084,459 B2Granted
Substituted quinazolinones for treating neurological conditions
AssigneePrana Biotechnology Limited
InventorsGaik Beng Kok, Brenda Kwan Yi Leung
Life of this patent
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Abstract
Compounds of the formula or salts, tautomers or isomers thereof, are useful for treating neurological conditions, especially neurodegenerative disorders, such as Alzheimer's disease.
Claims5
A compound of the formula
- or pharmaceutically acceptable salts, tautomers or stereoisomers thereof, in which
- R2 is CH2NR1R4 in which R1 and R4 are independently selected from H and C1-3 alkyl;
- R3 is optionally substituted C1-4 alkyl;
- R5 and R7 are chloro;
- and
- X is O
- wherein the optional substituents are independently selected from alkyl, alkenyl, alkynyl, aryl, formyl, halo, haloalkyl, haloalkenyl, haloalkynyl, haloaryl, hydroxy, alkoxy, alkenyloxy, aryloxy, benzyloxy, haloalkoxy, haloalkenyloxy, haloaryloxy, nitro, nitroalkyl, nitroalkenyl, nitroalkynyl, nitroaryl, nitroheterocyclyl, amino, alkylamino, dialkylamino, alkenylamino, alkynylamino, arylamino, diarylamino, benzylamino, dibenzylamino, acyl, alkenylacyl, alkynylacyl, arylacyl, acylamino, diacylamino, acyloxy, alkylsulphonyloxy, arylsulphenyloxy, heterocyclyl, heterocyclyloxy, heterocyclylamino, haloheterocyclyl, alkylsulphenyl, arylsulphenyl, carboalkoxy, carboaryloxy, mercapto, alkylthio, benzylthio and acylthio.
4 more elements
Dependencies are inferred from the claim text.