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US 8,080,428 B2Granted
Investigation of mucosa dryness conditions
AssigneesSingapore Health Services Pte Ltd, Agency for Science, Technology and Research
InventorsRoger Beuerman, Lei Zhou, Shouping Liu, He Yang, Donald Tan
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Abstract
The present invention relates to diagnosis and/or treatment of medical conditions. The present invention relates to new method of diagnosing dry mucosa condition in a subject. The condition may be dry eye. The present invention also provides a method to monitor the efficacy of a treatment of a dry mucosa condition, a method of treating a dry mucosa condition and/or a diagnostic kit for a dry mucosa condition.
Claims8
A method of diagnosing dry eye in a subject, the method comprising:
- (i) providing a tear fluid sample from said subject;
- (ii) measuring the expression of α-enolase in said sample by mass spectrometry;
- and
- (iii) comparing expression of α-enolase from said sample to a reference value from a statistically significant number of control subjects not exhibiting signs or experiencing symptoms of dry eye, wherein the subject is diagnosed with dry eye if a ratio of α-enolase from said sample to said reference value is greater than 1.70.
1 more element
Dependencies are inferred from the claim text.