Method and arrangement for the online regulation of a batch process in a bioreactor

A system for online regulation of a batch processes in a bioreactor, comprising:

• an near-infrared range (NIR) mass spectrometer that records spectra of the current batch in the bioreactor at consecutive points in time during an ongoing batch process;
• an analysis device for primary component analysis of a high-dimensional spectra;
• a creating device for creating a measuring vector for each spectrum in a low-dimensional primary component region;
• a determining device for deter mining a deviation between the measuring vector and a corresponding vector of a nominal trajectory that consists of a measuring vector of a reference batch determined from a previous batch process;
• an adjustment determining device for determining an adjustment operation for the batch process depending on the deviation;
• and
• a control device for executing the adjustment operation in the batch process, wherein the direction of the adjustment operation is retained if the deviation determined from one point in time to the other point in time is lower, and with the direction of the adjustment operation being changed if the deviation determined from one point in time to the other point in time remains the same or is higher.