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US 8,078,258 B2Granted
Assessment of vascular compartment volume for PET modelling
AssigneeSiemens Medical Solutions USA, Inc.
InventorsJerome Declerck, Kevin Scott Hakl
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Abstract
A method is described for acquiring and analysing the data produced by Positron Emission Tomography (PET), which method provides for an accurate estimation of vascular compartment volume, VB. An MRI scan and the PET scan is performed simultaneously and the results of the former is used to derive a value for VB. The value so derived is then used in pharmacokinetic modelling along with the results of the functional scan.
Claims5
A method of processing a set of Positron Emission Tomography (PET) scan images comprising the steps of:
- administering a PET scan contrast agent and a magnetic resonance imaging (MRI) contrast agent to a subject;
- simultaneously performing a PET scan and an MRI scan on the subject to generate PET scan images and corresponding data from the MRI scan;
- calculating VB, the fraction of pixel volume occupied by blood vessels, using data acquired from the MRI scan;
- and
- performing pharmacokinetic analysis based on i) the value of VB so derived and ii) the PET scan images.
2 more elements
Apparatus comprising:
- a PET scanner;
- an MRI scanner, said PET scanner and said MRI scanner being configured to perform simultaneous scans of a subject;
- and
- a processor;
- wherein the process is configured,
- to receive data from each of the PET scanner and the MRI scanner;
- to calculate VB, the fraction of pixel volume occupied by blood vessels, using the data acquired during the MRI scan;
- and
- to perform pharmacokinetic analysis based on i) the value of VB so derived, and ii) the PET scan images.
6 more elements
Dependencies are inferred from the claim text.