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US 8,078,244 B2Granted
Interferometric method and instrument for measurement and monitoring blood glucose through measurement of tissue refractive index
AssigneeNewton Photonics, Inc.
InventorsPaul Melman, Stephen Cohen
Life of this patent
Estimating the term…
Abstract
A method of measuring glucose concentration in tissue includes measuring scattering coefficients of the tissue at each of a plurality of temperatures and at a selected tissue depth using optical coherence tomography, and determining the glucose concentration in interstitial fluid of the tissue as a function of the measured scattering coefficients.
Claims22
A method of measuring glucose concentration in tissue comprising:
- measuring scattering coefficients of the tissue at each of a plurality of temperatures and at a selected tissue depth using optical coherence tomography;
- and determining the glucose concentration in interstitial fluid of the tissue as a function of the plurality of measured scattering coefficients, wherein said measured scattering coefficients are measured at each of said plurality of temperatures before physiological effects occur to said tissue.
A system for measuring glucose concentration in tissue comprising:
- a probe for applying a plurality of temperatures to the tissue;
- and an instrument for measuring a scattering coefficient of light scattered by the tissue at each of the plurality of temperatures at a selected tissue depth using an optical coherence tomography system, and for determining the glucose concentration in interstitial fluid of the tissue as a function of the plurality of measured scattering coefficients, wherein said measured scattering coefficients are measured at each of said plurality of temperatures before physiological effects occur to said tissue.
Dependencies are inferred from the claim text.