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US 8,076,637 B2Granted
Mass spectrometer
AssigneeMicromass UK Limited
InventorsSteven Derek Pringle, Jason Lee Wildgoose
Life of this patent
Estimating the term…
Abstract
A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals (13, 14, 15) having a plurality of frequency notches (16a; 16b; 16c) are applied sequentially to the rods of the quadrupole rod set. The notched broadband frequency signals (16a, 16b, 16c) cause undesired ions to be resonantly or parametrically ejected from the ion guide. The resulting ion signals are deconvoluted to provide a mass spectrum.
Claims15
A method of guiding or mass filtering ions comprising:
- providing an ion guide or mass filter device comprising a plurality of electrodes or rods;
- applying an RF voltage to said plurality of electrodes or rods;
- supplying a plurality of signals to said plurality of electrodes or rods, wherein said step of supplying said plurality of signals comprises at least the steps of:
- (i) supplying a first signal to said plurality of electrodes or rods in order to resonantly or parametrically excite undesired ions within or from said ion guide or mass filter device, said first signal comprising a plurality of frequency notches, and obtaining a first set of data;
- and then
- (ii) supplying a second different signal to said plurality of electrodes or rods in order to resonantly or parametrically excite undesired ions within or from said ion guide or mass filter device, said second signal comprising a plurality of frequency notches, and obtaining a second set of data;
- and
- deconvoluting, decoding or demodulating said first set of data and said second set of data to determine the intensity of ions having a plurality of different mass to charge ratios.
5 more elements
An ion guide or mass filter device comprising:
- a plurality of electrodes or rods;
- an RF voltage supply for supplying an RF voltage to said plurality of electrodes or rods;
- signal means arranged and adapted:
- (i) to supply a first signal comprising a plurality of frequency notches to said plurality of electrodes or rods in order to resonantly or parametrically excite undesired ions within or from said ion guide or mass filter device and wherein a first set of data is obtained;
- and then
- (ii) to supply a second different signal comprising a plurality of frequency notches to said plurality of electrodes or rods in order to resonantly or parametrically excite undesired ions within or from said ion guide or mass filter device and wherein a second set of data is obtained;
- and
- a device for deconvoluting, decoding or demodulating said first set of data and said second set of data to determine the intensity of ions having a plurality of different mass to charge ratios.
5 more elements
A method of guiding or mass filtering ions comprising:
- modulating, varying or synthesising a broadband frequency signal wherein a plurality of signals each having two or more frequency notches are sequentially generated and applied to an ion guide or mass filter device;
- detecting ions transmitted by said ion guide or mass filter using an ion detector;
- and
- demodulating, deconvoluting, decoding or deconstructing a signal output by said ion detector in order to determine the intensity of ions having a plurality of different mass to charge ratios.
1 more element
Apparatus comprising:
- an ion guide or mass filter device;
- a device for modulating, varying or synthesising a broadband frequency signal wherein a plurality of signals each having two or more frequency notches are sequentially generated and applied to said ion guide or mass filter device;
- an ion detector for detecting ions transmitted by said ion guide or mass filter;
- and
- a device for demodulating, deconvoluting, decoding or deconstructing a signal output by said ion detector in order to determine the intensity of ions having a plurality of different mass to charge ratios.
2 more elements
Dependencies are inferred from the claim text.