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US 8,076,514 B2Granted
Phenyl compounds and their use in the treatment of Type II diabetes
AssigneeEli Lilly and Company
InventorsLarry Chris Blaszczak, Shon Roland Pulley, Michael Alan Robertson, Scott Martin Sheehan, Qing Shi, Brian Morgan Watson, Michael Robert Wiley
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Abstract
The present invention is directed to compounds of formula (I) or a pharmaceutically acceptable salt thereof; wherein A is (xx); X is selected from CH, CF and N, R5 is selected from H, C1-C6 alkyl, C1-C6 fluoroalkyl, and —OR12, R9 is selected from H and —C(O)NR1OR1 1, R12 is selected from H, C1-C6 alkyl and C3-C6 cycloalkyl for use as inhibitors of the DPP-IV enzyme in the treatment or prevention of conditions including Type II diabetes.
Claims17
A compound of the formula I:
- or a pharmaceutically acceptable salt thereof,
- wherein
- A is
- R1 is halo;
- R2, R3, and R4 are independently selected from H and halo;
- X is CH;
- R5 is —OR12;
- R6 is selected from H, halo, C1-C6 alkyl, and C1-C6 alkoxy;
- R7 and R8 are independently selected from H, halo, and C1-C6 alkyl;
- R9 is —C(O)NR10R11;
- R10 and R11 are independently selected from H and C1-C6 alkyl;
- R12 is selected from H and C1-C6 alkyl;
- and R13 is H.
10 more elements
Dependencies are inferred from the claim text.