Methods for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives
AssigneeTibotec Pharmaceuticals Ltd.
InventorsHartmut Burghard Zinser, Peter Hermann Hölzle
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Abstract
A process for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives in which a (1-benzyl-2-hydroxy-3-isobutylamino-propyl)-carbamic acid derivative is reacted with a p-nitrophenylsulfonyl halide to provide the desired product in a high yield and degree of purity.
Claims9
A process for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives of formula (I) which comprises reacting a compound of formula (II) with a compound of formula (III) in a water-miscible solvent comprising a secondary or tertiary alcohol:
- in which PG is a protecting group and X is a halogen atom.
Dependencies are inferred from the claim text.