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US 8,076,484 B2Granted
Modified green tea polyphenol formulations
AssigneeGeorgia Health Science University Research Institute, Inc.
InventorStephen D. Hsu
Life of this patent
Estimating the term…
Abstract
Modified green tea polyphenols and methods of their use are provided. One aspect provides compounds and compositions containing green tea polyphenols with one on more ester-linked fatty acids.
Claims8
A composition comprising:
- (a) one or more compounds according to Formula II:
- Wherein R1, R2, R3, R4, R7, R8, R9, and R10 are each independently H, OH,
- R11 is a linear, branched, or cyclic, saturated or unsaturated, substituted or unsubstituted C1-C30 group, wherein if R11 is cyclic, R11 is a C3-C30 group;
- R5 is O, —NR12R13 or S, wherein R12 and R13 are independently hydrogen, or a linear, branched, or cyclic, saturated or unsaturated, substituted or unsubstituted C1-C30 group, wherein if R12 and/or R13 are cyclic, R12 and/or R13 are C3-C30 groups;
- R6 is independently O or S;
- wherein at least one of R1, R2, R3, R4, R7, R8, R9, or R10 are independently
- provided R4 is not
- when R1, R2, R3, R7, R8, R9, and R10 are OH;
- or a pharmaceutically acceptable salt thereof;
- and
- (b) an excipient.
8 more elements
A compound according to formula II:
- wherein R1, R2, R3, R4, R7, R8, R9, and R10 are each independently H, OH,
- R11 is a linear, branched, or cyclic, saturated or unsaturated, substituted or unsubstituted C1-C30 group, wherein if R11 is cyclic, R11 is a C3-C30 group;
- R5 is O, —NR12R13 or S, wherein R12 and R13 are independently hydrogen, or a linear, branched, or cyclic, saturated or unsaturated, substituted or unsubstituted C1-C30 group, wherein if R12 and/or R13 are cyclic, R12 and/or R13 are C3-C30 groups;
- R6 is independently O or S;
- wherein at least one of R1, R2, R3, R4, R7, R8, R9, or R10 are independently
- provided R4 is not
- when R1, R2, R3, R7, R8, R9, and R10 are OH;
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.