Nucleic acid inhibitors of glutamate receptors
AssigneesThe Research Foundation of State University of New York, Cornell University
InventorsLi Niu, Zhen Huang, Hua Shi, John T. Lis
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Abstract
The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
Claims13
An isolated nucleic acid that binds to an α-amino-3-hydroxy-5-methyl-4-isoxazole proionate (AMPA) subtype glutamate receptor, wherein said nucleic acid is an RNA and comprises a nucleotide sequence selected from the group consisting of SEQ ID NO.:
- 1, SEQ ID NO.:
- 2, SEQ ID NO.:
- 3, SEQ ID NO.:
- 4, SEQ ID NO.:
- 5, SEQ ID NO.:
- 7, SEQ ID NO.:
- 8, SEQ ID NO.:
- 9, SEQ ID NO.:
- 10 and SEQ ID NO.:
- 11.
An isolated DNA that codes for an RNA wherein the RNA comprises a nucleotide sequence selected from the group of SEQ ID NOS.:
- 1 to 11.
Dependencies are inferred from the claim text.