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AssigneeKyowa Hakko Kirin Co., Ltd.
InventorsSo Ohta, Hiroshi Ando, Masayo Suzuki, Shinobu Kawamoto, Mariko Nakano, Kazuyasu Nakamura
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An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as “CLDN4”) gene or a polypeptide encoded by a Claudin-3 (hereinafter referred to as “CLDN3”) gene, or a method for using the same. Accordingly, the present invention provides a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of an extracellular region of CLDN4 and binds to the extracellular region; a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of both of extracellular regions of CLDN3 and CLDN4 and binds to the extracellular regions; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtained by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by CLDN4 gene and/or CLDN3 gene using the antibody or the antibody fragment.
An isolated monoclonal antibody or an antibody fragment thereof, which competes with a monoclonal antibody produced by the hybridoma KM3900 (FERM BP-10751) in the binding to the extracellular region of Claudin-4 (CLDN4), and
An isolated monoclonal antibody or an antibody fragment thereof, which competes with a monoclonal antibody produced by the hybridoma KM3907 (FERM BP-10885) in the binding to the extracellular region of CLDN4, and
Dependencies are inferred from the claim text.