Fusion proteins comprising canine thymic stromal lymphopoietin protein and uses thereof
AssigneeIntervet Inc.
InventorsJeanine D. Mattson, Daniel M. Gorman, Rene de Waal Malefyt, Mohamad A. Morsey
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Abstract
The present invention discloses a canine TSLP protein and a nucleic acid that encodes that protein. Peptide fragments of the protein that comprise specific epitopes of the canine TSLP protein are also disclosed. The canine TSLP protein and related peptide fragments may be used as an antigen for immunological assays, as well as for vaccines that induce anti-TSLP antibodies. The present invention further discloses methods of making and using the canine TSLP gene, the canine TSLP protein, and the related peptide fragments.
Claims18
A fusion protein comprising a thymic stromal lymphopoietin protein (TSLP) or an antigenic fragment thereof, wherein said TSLP comprises an amino acid sequence that has 90% or greater identity to the amino acid sequence of SEQ ID NO:
- 2, excluding the 28 amino acid residue signal sequence;
- and
- wherein said TSLP is cross-reactive with an antibody raised against the canine TSLP comprising the amino acid of SEQ ID NO:
- 2.
A fusion protein comprising an antigenic fragment of a canine TSLP, wherein said antigenic fragment comprises the amino acid sequence of SEQ ID NO:64.
A nucleic acid molecule encoding a fusion protein comprising a thymic stromal Iymphopoietin protein (TSLP) or an antigenic fragment thereof wherein said TSLP corn rises an amino acid sequence that has 90% or greater identity to the amino acid sequence of SEQ ID NO:
- 2, excluding the 28 amino acid residue signal sequence;
- and wherein said TSLP is cross-reactive with an antibody raised against the canine TSLP comprising the amino acid of SEQ ID NO:
- 2.
A nucleic acid molecule encoding a fusion protein comprising an antigenic fragment of a canine TSLP, wherein said antigenic fragment comprises the amino acid sequence of SEQ ID NO:64.
Dependencies are inferred from the claim text.