Kinin B1 receptor peptide agonists and uses thereof

A compound of formula (1)

• aay-aax-aa0-aa1-aa2-aa3-aa4-aa5-Ser6-Pro7-D-Phe8-X (1)
• or a salt thereof;
• wherein:
• X is OH or NH2;
• aay is Sar, acetyl or other acyl group;
• aax is L-Arg, D-Arg, L-Lys, D-Lys, L-Orn, D-Orn, another basic amino acid of the L or D-configuration, L-Cit, D-Cit or is absent;
• aa0 is L-Arg, D-Arg, L-Lys, D-Lys, L-Orn, D-Orn, another basic amino acid of the L or D-configuration, or L-Cit, D-Cit;
• aa1 is L-Arg or D-Arg;
• aa2 is L-Pro, L-Oic, another L-Pro mimic amino acid, L-Hyp, L-α-(Me)Pro or another Pro-mimic amino acid derivative chosen from 5,5-dimethylthiazolidine-4-carboxylic acid;
• 3,4-dehydro-proline;
• azetidine-2-carboxylic acid;
• trans-4-cyano-proline;
• cis-4-cyano-proline;
• 2-ethylthiazolidine-4-carboxylic acid;
• thiazolidine-2-carboxylic acid;
• 2-methylthiazolidine-4-carboxylic acid;
• and 3-phenylpyrrolidine-2-carboxylic acid;
• aa3 is L-Pro, or another L-Pro-mimic amino acid, L-Hyp, L-Oic, L-α-(Me)Pro or another Pro-mimic amino acid derivative chosen from 5,5-dimethylthiazolidine-4-carboxylic acid;
• 3,4-dehydro-proline;
• azetidine-2-carboxylic acid;
• trans-4-cyano-proline;
• cis-4-cyano-proline;
• 2-ethylthiazolidine-4-carboxylic acid;
• thiazolidine-2-carboxylic acid;
• 2-methylthiazolidine-4-carboxylic acid;
• and 3-phenylpyrrolidine-2-carboxylic acid;
• aa4 is Gly, ethyl amine, or Aib;
• aa5 is L-Phe, D-Phe, Acc, L-Cha, D-Cha, L-Chg, D-Chg, L-Cpg, D-Cpg, L-Igl, D-Igl, L-Pen, D-Pen, L-4Bip, D-4Bip, L-Phg, D-Phg, L-Thi, or D-Thi;
• and
• D-Phe8 is D-Phe;
• or
• -aa2-aa3-aa4- is an aliphatic ω-amino carboxyl residue with a chain length of 8 carbon atoms;
• and X, aay, aax, aa0, aa1, aa5, and D-Phe8 are as previously defined;
• or
• -aa2-aa3-aa4-aa5- is an aliphatic ω-amino carboxyl residue with a chain length of 11 carbon atoms;
• and X, aay, aax, aa0, aa1, and D-Phe8 are as previously defined.