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US 8,076,412 B2Granted
Water-soluble polymer alkanals
AssigneeNektar Therapeutics
InventorAntoni Kozlowski
Life of this patent
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Abstract
The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepared in high purity and exhibit storage stability.
Claims28
A method of forming a water-soluble polymer alkanal, said method comprising the steps of:
- reacting a water soluble polymer comprising at least one reactive group, Y, with a protected alkanal reagent comprising from about 2 to 20 carbon atoms and a reactive group, K, suitable for displacement by or alternatively, reaction with Y, under conditions effective to form a water soluble polymer alkanal in protected form.
Dependencies are inferred from the claim text.