Self-setting polymeric cyanoacrylate composites
AssigneePoly-Med, Inc.
InventorsShalaby W Shalaby, Michael Aaron Vaughn, Shawn J Peniston, Sheila Nagatomi
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Abstract
Self-setting, absorbable bioactive polycyanoacrylate-based composites include at least one inorganic phosphate salt or a combination of at least one inorganic phosphate salt and calcium silicate in a cyanoacrylate matrix. The composites can be reinforced with single- or multicomponent absorbable, warp-knitted mesh, thus producing a broad range of absorbable, bioactive biomaterials suitable for use not only as preferred absorbable alternatives to the commercial non-absorbable polymethyl methacrylate bone cements, but also for repairing or replacing cranial and maxillofacial bone defects and other complex defects through guided bone regeneration.
Claims12
An absorbable, self-setting, bioactive composite paste comprising at least 20 percent by weight of mixed solid calcium silicate microparticles in a cyanoacrylate matrix, the mixed solid microparticles further comprising at least one inorganic phosphate, the cyanoacrylate matrix comprising a liquid cyanoacrylate comprising an alkoxyalkyl cyanoacrylate;
- and wherein the liquid cyanoacrylate comprises methoxypropyl cyanoacrylate and the at least one inorganic phosphate comprises anhydrous basic calcium phosphate (CaHPO4), and the mixed solid microparticles further comprise an anionic initiator selected from the group consisting of dibasic potassium phosphate, dibasic sodium phosphate, and hydroxy-terminated polyglycolide (PG-H).
An absorbable, self-setting, bioactive composite comprising at least 20 percent by weight of mixed solid microparticles in polymeric cyanoacrylate matrix, the mixed solid microparticles comprising at least one inorganic phosphate and calcium silicate, and the cyanoacrylate matrix derived from a liquid cyanacrylate comprising an alkoxyalkyl cyanoacrylate, in the form of a partially cured paste that further comprises a reinforcing absorbable, wrap-knitted mesh, constructed from at least one yarn selected from the group consisting of those made of chitosan, silk, a high lactide-based segmented copolyester, a high glycolide-based copolymer, high glycolide-based segmented polyaxial copolymer, and segmented polyether-ester.
An absorbable, self-setting, bioactive composite paste comprising at least 20 percent by weight of mixed solid calcium silicate microparticles in a cyanoacrylate matrix, the mixed solid microparticles further comprising at least one inorganic phosphate, the cyanoacrylate matrix comprising a liquid cyanoacrylate comprising an alkoxyalkyl cyanoacrylate, wherein the paste is in the form of sterilized components for use as a bone cement and filler.
An absorbable, self-setting, bioactive composite paste comprising at least 20 percent by weight of mixed solid calcium silicate microparticles in a cyanoacrylate matrix, the mixed solid microparticles further comprising at least one inorganic phosphate, the cyanoacrylate matrix comprising a liquid cyanoacrylate comprising an alkoxyalkyl cyanoacrylate, and wherein the liquid cyanoacrylate comprises methoxypropyl cyanoacrylate and the at least one inorganic phosphate comprises anhydrous basic calcium phosphate (CaHPO4), and the mixed solid microparticles further comprise an anionic initiator selected from the group consisting of dibasic potassium phosphate, dibasic sodium phosphate, and hydroxy-terminated polyglycolide (PG-H);
- and the paste is in the form of sterilized components for use as a bone cement and filler.
Dependencies are inferred from the claim text.