Percutaneous absorption type cerebral protective agent
AssigneeLead Chemical Co., Ltd.
InventorsJun Mori, Tamaki Horiuchi, Seijiro Yama, Hitomi Waki, Shingo Shimada, Hitomi Hashitani
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Abstract
A percutaneous absorption type cerebral protective agent containing as an active ingredient, 0.1 to 30 percent by mass of 3-methyl-1-phenyl-2-pyrazolin-5-one represented by the following formula: or a medically acceptable salt thereof in a base; a use of the compound as an active ingredient for the manufacture of a percutaneous absorption type pharmaceutical composition for protecting brain; and a method of protecting brain comprising administering to a patient the pharmaceutical composition as an active ingredient.
Claims12
A method of protecting against cerebral dysfunction, comprising:
- administering to a patient in need of protecting against cerebral dysfunction a percutaneous absorption type pharmaceutical composition that comprises, as an active ingredient, 3-methyl-1-phenyl-2-pyrazolin-5-one represented by the following formula:
- or a medically acceptable salt thereof,
- the active ingredient being present in an amount of 0.5 to 10 percent by mass in an aqueous base, the aqueous base comprising, based on a total amount of the aqueous base:
- 1 to 20 percent by mass of a water-soluble polymer,
- 0.01 to 20 percent by mass of a cross-linking agent,
- 10 to 80 percent by mass of polyhydric alcohol, and
- 1 to 80 percent by mass of water,
- wherein the percutaneous absorption type pharmaceutical composition further comprises one or more of talc, lactic acid, isopropanol and polysorbate 80.
Dependencies are inferred from the claim text.