6-substituted-thio-2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE)

A compound of formula (I)

• wherein
• R1 is selected from the group consisting of C1-4alkyl, C3-8cycloalkyl, 5-6 membered heteroaryl, —(C1-4alkyl)-(5-6 membered heteroaryl), 5-6 membered heterocycloalkyl and —(C1-4alkyl)-5-6 membered heterocycloalkyl;
• R2 is selected from the group consisting of hydrogen and halogen;
• L1 is selected from the group consisting of —CH2—NRA—, —CH2CH2—NRA, —CH2—O— and —CH2—S—;
• wherein RA is selected from the group consisting of hydrogen, C1-4alkyl, —C(O)—C1-4alkyl, —C(O)O—C1-4alkyl and —SO2—C1-4alkyl;
• R3 is selected from the group consisting of C1-4alkyl, carboxy substituted C1-4alkyl, C4-8cycloalkyl, —(C1-4alkyl)-C4-8cycloalkyl, partially unsaturated carbocyclyl, —(C1-4alkyl)-(partially unsaturated carbocyclyl), aryl, —(C1-4alkyl)-aryl, heteroaryl, —(C1-4alkyl)-heteroaryl, heterocycloalkyl and —(C1-4alkyl)-heterocycloalkyl;
• wherein the C4-8cycloalkyl, aryl, heteroaryl or heterocycloalkyl, whether alone or as part of a substituent group is optionally substituted with one or more substituents independently selected from the group consisting of halogen, hydroxy, carboxy, C1-4alkyl, fluorinated C1-4alkyl, —C1-4alkoxy-, fluorinated —C1-4alkoxy, —C1-4alkyl-OH, —C1-4alkyl-CO2H and phenyl;
• alternatively, RA and R3 are taken together with the nitrogen atom to which they are bound to form a ring selected from the group consisting of 5 to 6 membered heteroaryl and 5 to 6 membered heterocycloalkyl;
• or a pharmaceutically acceptable salt thereof.