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US 8,076,355 B2Granted
2-heteroarylcarboxylic acid amides
AssigneeBayer Schering Pharma Aktiengesellschaft
InventorsMartin Hendrix, Frank-Gerhard Böβ, Christina Erb, Timo Fleβner, Marja Van Kampen, Joachim Luithle, Christoph Methfessel, Welf-Burkhard Wiese
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Abstract
The invention relates to novel 2-heteroarylcarboxamides, processes for their preparation, and their use for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
Claims18
A method for treating a cognitive impairment in a patient suffering from Alzheimer's disease or schizophrenia, the method comprising administering to a patient a therapeutically effective amount a compound of formula (I):
- wherein
- R1 represents 1-azabicyclo[2.2.2]oct-3-yl,
- R2 represents hydrogen or C1-C6-alkyl,
- R3 represents hydrogen, halogen or C1-C6-alkyl,
- A represents oxygen or sulfur,
- and
- the ring B represents benzo, pyrimido, pyrimidazo or pyridazino which is substituted by a radical selected from the group consisting of halogen, C1-C6-alkanoyl, carbamoyl, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6-acylamino, C1-C6-alkyl, C1-C6-alkyoxy, C1-C6-alkylthio, C1-C6-alkylamino, heteroarylcarbonylamino, arylcarbonylamino, C1-C6-alkylsulfonyl-amino, di(C1-C4-alkylsulfonyl)amino, arylsulfonylamino, di(arylsulfonyl)amino, C3-C6-cycloalkylcarbonylmethyl, 1,3-dioxa-propane-1,3-diyl, amino(hydroxyimino)methyl and benzo,
- or a salt, a hydrate or a hydrate of a salt thereof.
5 more elements
Dependencies are inferred from the claim text.