Compounds and methods for the treatment of cancer
AssigneesUniversity of Georgia Research Foundation, Inc., Yale University
InventorsChung K. Chu, Yung-chi Cheng
Life of this patent
Estimating the term…
Abstract
(−)-(2S,4S)-1-(2-Hydroxymethyl-1,3-dioxolan-4-yl)cytosine (also referred to as (−)-OddC) or its derivative and its use to treat cancer in animals, including humans.
Claims20
A method for treating a cancer selected from the group consisting of lung cancer, colorectal cancer, breast cancer, prostate cancer, bladder cancer, pancreatic cancer, ovarian cancer, uterine cancer, leukemia, CNS cancer, melanoma, renal cancer, lymphoma and head and neck cancer in a host animal comprising administering to said animal an effective amount of a compound of the formula
- wherein R1 and R2 are independently selected from the group consisting of an acyl group in which the non-carbonyl moiety of the ester group is selected from straight, branched, or cyclic C1 to C18 alkyl, methoxymethyl, phenoxymethyl or phenyl;
- a sulfonate ester, and mono, di and triphosphate ester said cancer being sensitive to treatment with said compound.
A method for treating a cancer selected from the group consisting of lung cancer, colorectal cancer, breast cancer, prostate cancer, bladder cancer, pancreatic cancer, ovarian cancer, uterine cancer, leukemia, CNS cancer, melanoma, renal cancer, lymphoma and head and neck cancer in a human comprising administering to said human an effective amount of a compound of the formula
- wherein R1 and R2 are independently selected from the group consisting of an acyl group in which the non-carbonyl moiety of the ester group is a straight, branched, or cyclic C1 to C18 alkyl group, methoxymethyl, phenoxymethyl or phenyl;
- a sulfonate ester, and mono, di and triphosphate ester, said cancer being sensitive to treatment with said compound.
Dependencies are inferred from the claim text.