Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid
AssigneeTaro Pharamaceutical Industries Ltd.
InventorsDaniella Gutman, Barrie Levitt, Daniel A. Moros, Avraham Yacobi, Howard Rutman
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Abstract
The present invention relates to a composition and a method of delivering a barbituric acid derivative to the central nervous system of a mammal in need of treatment for neurological conditions. In particular, the present invention relates to a method of administering an oral dosage form of a sodium salt of 5,5-diphenyl barbituric acid to enhance the bioavailability of 5,5-diphenyl barbituric acid and brain delivery of same.
Claims27
An oral dosage form comprising a salt of 5,5-diphenyl barbituric acid and a pharmaceutically acceptable excipient, wherein the oral dosage form is selected from the group consisting of a tablet, pill, capsule, caplet, powder, granule, suspension, gel and soft gel.
A pharmaceutical product comprising a salt form of 5,5-diphenyl barbituric acid, wherein the pharmaceutical product is selected from the group consisting of a tablet, pill, capsule, caplet, powder, granule, suspension, gel and soft gel.
Dependencies are inferred from the claim text.