2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof

A compound according to formula 1:

• wherein
• R1 is aryl or heteroaryl unsubstituted or substituted with one or more R4 groups;
• R2 is H, substituted or unsubstituted C1-C6 alkyl or cycloalkyl;
• each R3 and R4 is independently selected from the group consisting of H, alkyl, acyl, acylamino, alkylamino, alkylthio, alkoxy, alkoxycarbonyl, alkylarylamino, arylalkyloxy, arylalkyloxy, amino, aryl, arylalkyl, —SO3H, —SO3R61b, wherein R61b is a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, —S(O2)R61, wherein R61 is a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, —SOR61a, wherein R61a is a substituted or unsubstituted alkyl, a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl,
• —SR, wherein R is a substituted or unsubstituted alkyl, a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl, azido, carbamoyl, carboxyl, cyano, cycloalkyl, cycloheteroalkyl, dialkylamino, halo, heteroaryloxy, heteroaryl, heteroalkyl, hydroxy, nitro, and SH;
• and m is 1, 2, 3, or 4;
• or a pharmaceutically acceptable salt, tautomer or isotopic variant thereof.