Prodrugs of thyroid hormone analogs
AssigneeHoffmann-La Roche Inc.
InventorsNancy-Ellen Haynes, Nathan Scott, Jefferson Wright Tilley
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Abstract
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
Claims18
A compound of formula (I):
- wherein:
- R1 is —OH, O-linked amino acid, —OP(O)(OH)2 or —OC(O)—R2;
- R2 is lower alkyl, alkoxy, alkyl acid, cycloalkyl, heterocycloalkyl, —(CH2)n-heterocycloalkyl, aryl, heteroaryl, or —(CH2)n-heteroaryl;
- and
- n is 0 or 1;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.