Dipeptidyl peptidase-IV inhibitors

A compound of formula (I):

• A-B-D (I)
• or a pharmaceutically acceptable salt thereof,
• wherein A is:
• B is:
• D is:
• Y is divalent and is:
• a bond, CR4R5, O, NR4, S, S═O, S(═O)2, C(═O), (C═O)N(R4), S(═O)2N(R4), C═N—OR4, —C(R4R5)C(R4R5)—, —C(R4R5) C(R4R5)C(R4R5)—, —C(R4R5)C(R4R5)C(R4R5)C(R4R5)—, —C(R4)═C(R5)—, —C(R4R5)NR4—, —C(R4R5)O—, —C(R4R5)S(═O)t—, —(C═O)O—, —(C═NRa)N(R4)—, —(C═NRa)—, N(C═O)NR4NR5, N(C═O)R4, N(C═O)OR4, NS(═O)2NR4NR5, or NS(═O)2R4;
• R1 and R2 are independently:
• hydrogen, —F, —Cl, —CONR4R5, or —CO2R4;
• R3 is CONR4R5, tetrazolyl or oxadiazolonyl;
• Ra is hydrogen, CN, NO2, alkyl, haloalkyl, S(O)tNR4R5, S(O)tR4, C(O)OR4, C(O)R4, or C(O)NR4R5;
• each occurrence of R4 and R5 are each independently:
• hydrogen or alkyl, or R4 and R5 when taken together with a nitrogen to which they are attached form a 3- to 8-membered ring containing carbon atoms and may optionally contain a heteroatom selected from O, S, or NR50;
• R50 is, in each occurrence, R20, CN, NO2, S(O)tNR20R21, S(O)tR20, C(O)OR20, C(O)R20C(═NRa)NR20R21, C(═NR20)NR21Ra, C(═NOR20)R21 or C(O)NR20R21;
• each occurrence of R20 and R21 are each independently:
• hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, fluoroalkyl, heterocycloalkylalkyl, alkynyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl or aminoalkyl;
• each occurrence of R7 and R8 are each independently:
• halogen, CF3, COR4, OR4, NR4R5, NO2, CN, SO2OR4, CO2R4, CONR4R5, CO2H, SO2NR4R5, S(O)tR4, SO3H, OC(O)R4, OC(O)NR4R5, NR4C(O)R5, NR4CO2R5, (C0-C6)-alkyl-C(═NRa)NHR4, (C0-C6)-alkyl-C(═NR4)NHRa, (C0-C6)-alkyl-NR4C(═NR4)NR4R5, (C0-C6)-alkyl-C(O)OR4, (C0-C6)-alkyl-C(O)NR4R5, (C0-C6)-alkyl-C(O)—NH—CN, O—(C0-C6)-alkyl-C(O)NR4R5, S(O)t—(C0-C6)-alkyl-C(O)OR4, S(O)t—(C0-C6)-alkyl-C(O)NR4R5, (C0-C6)-alkyl -C(O)NR4—(C0-C6)-alkyl-NR4R5, (C0-C6)-alkyl -NR4R5, (C0-C6)-alkyl-NR4—C(O)R5, (C0-C6)-alkyl-NR4—C(O)OR4, (C0-C6)-alkyl-NR4—C(O)—NR4R5, (C0-C6)-alkyl-NR4—SO2NR4R5, (C0-C6)-alkyl-NR4—SO2R4, hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, fluoroalkyl, heterocycloalkylalkyl, haloalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, alkoxyalkyl or aminoalkyl, wherein alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, fluoroalkyl, heterocycloalkylalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, alkoxyalkyl or aminoalkyl;
• R9 is H or C1-6 alkyl;
• R10 is halogen, CF3, COR4, OR4, NR4R5, NO2, CN, SO2OR4, CO2R4, CONR4R5, CO2H, SO2NR4R5, S(O)tR4, SO3H, OC(O)R4, OC(O)NR4R5, NR4C(O)R5, NR4CO2R5, (C0-C6)-alkyl -C(═NRa)NHR4, (C0-C6)-alkyl-C(═NR4)NHRa, (C0-C6)-alkyl-NR4C(═NR4)NR4R5, (C0-C6)-alkyl-C(O)OR4, (C0-C6)-alkyl-C(O)NR4R5, (C0-C6)-alkyl-C(O)—NH—CN, O—(C0-C6)-alkyl-C(O)NR4R5, S(O)t—(C0-C6)-alkyl-C(O)OR4, S(O)t—(C0-C6)-alkyl-C(O)NR4R5, (C0-C6)-alkyl-C(O)NR4—(C0-C6)-alkyl-NR4R5, (C0-C6)-alkyl-NR4R5, (C0-C6)-alkyl-NR4—C(O)R5, (C0-C6)-alkyl-NR4—C(O)OR4, (C0-C6)-alkyl-NR4—C(O)—NR4R5, (C0-C6) -alkyl-NR4—SO2NR4R5, (C0-C6)-alkyl-NR4—SO2R4, hydrogen, B(OH)2, alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, fluoroalkyl, heterocycloalkylalkyl, haloalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, alkoxyalkyl or aminoalkyl;
• Qb is CH or N;
• U is —C(O)—, —C(═NR4)—, —(CR4R5—)p, NR50, S(═O)2, C(═O), (C═O)N(R4), N(R4)(C═O), S(═O)2N(R4), N(R4)S(═O)2, C═N—OR4, —C(R4)═C(R5)—, —C(R4R5)pNR50—, N(R50)C(R4R5)p—, —O—C(R4R5)—, —C(R4R5)S(═O)t—, —(C═O)O—, —(C═NRa)N(R4)—, —(C═NRa)—, N(C═O)NR4NR5, N(C═O)R4, N(C═O)OR4, NS(═O)2NR4NR5, or NS(═O)2R4;
• W is —CH2—, —S—, —CHF— or —CF2—;
• Z is C;
• p is 0 to 6;
• and
• t is 0, 1, or 2.