Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them

A compound of the formula I,

• in which
• Ar1 and Ar2, which are independent of one another and can be identical or different, are phenyl, naphthyl or heteroaryl, which are all optionally substituted by 1, 2, 3 or 4 identical or different substituents from the series consisting of halogen, cyano, (C1-C5)-alkyl, (C2-C5)-alkenyl, (C3-C8)-cycloalkyl-CvH2v—, Ar3, (C1-5)-alkyl-O—, HO—(C1-C5)-alkyl-O—, —O—(C1-C3)-alkyl-O—, (C3-C8)-cycloalkyl-S(O)f—, (C1-C5)-alkyl-S(O)k— and R11R12N—S(O)2—, wherein all alkyl groups, alkenyl groups and cycloalkyl groups in Ar1 and Ar2 are optionally substituted by one or more fluorine substituents;
• Ar3 and Ar5, which are independent of one another and can be identical or different, are phenyl or monocyclic heteroaryl, which are all optionally substituted by 1, 2 or 3 identical or different substituents from the series consisting of halogen, cyano, (C1-C5)-alkyl, (C1C5)-alkyl-O—, —O—(C1-C3)-alkyl-O—, (C1-C5)-alkyl-S(O)m— and R13R14N—S(O)2—, wherein all alkyl groups in Ar3 and Ar5 are optionally substituted by one or more fluorine substituents;
• Ar4 is phenyl or heteroaryl, which are all optionally substituted by 1, 2, 3 or 4 identical or different substituents from the series consisting of halogen, cyano, (C1-C5)-alkyl, (C2-C5)-alkenyl, (C3-C8)-cycloalkyl-CwH2w—, Ar5, (C1-C5)-alkyl-O—, HO—(C1-C5)-alkyl-O—, —O—(C1-C3)-alkyl-O—, (C1-C5)-alkyl-S(O)n— and R15R16N—S(O)2—, wherein all alkyl groups, alkenyl groups and cycloalkyl groups in Ar4 are optionally substituted by one or more fluorine substituents;
• R1 is R3—, R4—O— or R5R6N—;
• R2 is hydrogen, (C1-C8)-alkyl, (C2-C8)-alkenyl, (C3-C8)-alkynyl, phenyl-(C2-C8)-alkenyl-, Ar4, R17—O—(C1-C8)-alkyl-, R18R19N—(C1-C8)-alkyl-, Het-CuH2u— or (C3-C8)-cycloalkyl-CuH2u—, wherein the phenyl group in phenyl-(C2-C8)-alkenyl- is optionally substituted by 1, 2 or 3 identical or different substituents from the series consisting of halogen, cyano, (C1-C5)-alkyl, (C1-C5)-alkyl-O— and (C1-C5)-alkyl-S(O)g—, and wherein all alkyl groups, alkenyl groups, alkynyl groups and cycloalkyl groups in R2 are optionally substituted by one or more fluorine substituents;
• R3, R4, R5 and R6, which are all independent of one another and can be identical or different, are hydrogen, (C1-C8)-alkyl or (C3-C8)-cycloalkyl-CpH2p—, wherein all alkyl groups and cycloalkyl groups in R3, R4, R5 and R6 are optionally substituted by one or more fluorine substituents;
• R11, R12, R13, R14, R15, R16, R17, R18 and R19, which are all independent of one another and can be identical or different, are hydrogen, (C1-C8)-alkyl or (C3-C8)-cycloalkyl-CqH2q—, wherein all alkyl groups and cycloalkyl groups in R11, R12, R13, R14, R15, R16, R17, R18 and R19 are optionally substituted by one or more fluorine substituents;
• Het is a residue of a monocyclic 4-membered to 7-membered saturated ring which contains 1 or 2 identical or different ring heteroatoms from the series consisting of nitrogen, oxygen and sulfur, which is bonded via a ring carbon atom and which is optionally substituted by 1, 2, 3 or 4 identical or different substituents from the series consisting of phenyl and (C1-C5)-alkyl, wherein phenyl groups in Het are optionally substituted by 1, 2 or 3 identical or different substituents from the series consisting of halogen, cyano, (C1-C5)-alkyl, (C1-C5)-alkyl-O— and (C1-C5)-alkyl-S(O)h—, and wherein Het and all alkyl groups in Het are optionally substituted by one or more fluorine substituents;
• heteroaryl is a residue of a monocyclic 5-membered or 6-membered or of a bicyclic 8-membered, 9-membered or 10-membered aromatic ring system which contains 1, 2 or 3 identical or different ring heteroatoms from the series consisting of nitrogen, oxygen and sulfur;
• f, g, h, k, m and n, which are all independent of one another and can be identical or different, are 0, 1 or 2;
• p, q, v and w, which are all independent of one another and can be identical or different, are 0, 1, 2, 3 or 4;
• u is 0, 1, 2, 3, 4, 5 or 6;
• wherein all cycloalkyl groups, independently of any other substituents, are optionally substituted by one or more identical or different (C1-C4)-alkyl substituents;
• in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof;
• provided that Ar1 and Ar2 cannot both be unsubstituted phenyl if simultaneously R1 is hydroxy and R2 is hydrogen.