Anti-inflammatory agents
AssigneeCambridge Enterprise Limited
InventorsDavid J. Grainger, David John Fox
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AssigneeCambridge Enterprise Limited
InventorsDavid J. Grainger, David John Fox
Estimating the term…
The invention provides compounds, pharmaceutical compositions and uses of compounds and salts thereof of general formula (I), for the preparation of a medicament for treatment of an inflammatory disorder, but excluding (S)-3-(1′-methylcyclohexylcarbonylamino)-caprolactam: wherein z is 1, 2, 3 or 4; A is —CO— or —SO2—; Q is linear or branched alkyl, alkenyl, alkynyl, alkoxy, oxyalkyl, aminoalkyl, alkylamino, alklylaminoalkyl, haloalkyl, aryl or substituted aryl; T1 and T2 together constitute a cycloalkyl, cycloalkenyl or polycycloalkyl radical composed of n additional carbon atoms, where n is between 2 and 7; and each hydrogen atom bonded to the carbon atoms in the ring generated by T1 and T2 may be independently be substituted by a group R1, where R1 is independently selected from an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms; or each R1 is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical.
A method to treat or ameliorate an inflammatory disorder or a symptom thereof, comprising administering to a patient an effective amount of a compound of general formula (I) or a pharmaceutically acceptable salt thereof:
A method to treat or ameliorate an inflammatory disorder or a symptom thereof, comprising administering to a patient an effective amount of a compound of general formula (I′) or a pharmaceutically acceptable salt thereof:
Dependencies are inferred from the claim text.