Compositions and methods for modulating the immune system
OwnerPatrick T. Prendergastinventor
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Abstract
The present invention provides methods and compositions for the prophylaxis of blood cell disorders such as neutropenia, thrombocytopenia, lymphocytopenia, and anaemia. The invention provides methods wherein compositions comprising at least one cytokinin compound are administered either therapeutically or prophylactically. The invention further has utility in methods of DNA repair.
Claims18
A method for the treatment and/or prophylaxis of blood cell depletion, the method comprising:
- providing a therapeutically effective or prophylactically effective amount of oltipraz or a derivative, analogue, metabolite, prodrug or pharmaceutically acceptable salt thereof;
- and
- administering same to a subject in need thereof.
A pharmaceutical composition for use in the treatment of blood cell depletion, the composition comprising oltipraz in the form of metabolite 3 and a pharmaceutically acceptable diluent and/or carrier.
A method for the treatment and/or prophylaxis of blood cell depletion, the method comprising:
- providing a therapeutically or prophylactically effective amount of at least one cytokinin compound;
- and
- administering same to a subject in need thereof.
A combined pharmaceutical composition for the prevention and/or treatment and/or amelioration of a blood cell deficiency disorder, the composition comprising a cytokinin compound and a derivative or functionally equivalent analogue of oltipraz along with at least one pharmaceutically acceptable diluent, wherein the analogue or derivative of oltipraz is selected from the group consisting of 3H-1,2-dithiole-3-thione, sulforaphane, 5-(4-methoxyphenyl)-3H-1,2-dithiole-3-thione, ADT, ADO, 1,2-dithiole-3-thione, 1,2-dithiolane, 1,3-dithiole-2-thione and malotilate.
A method of stimulating cellular DNA repair mechanisms in a subject in advance of or following exposure of the subject to radiation, the method comprising the steps of:
- providing a therapeutically or prophylactically effective amount of a composition comprising oltipraz in the form of metabolite 3, and
- administering the composition to the subject.
A method of treating and/or preventing radiation-induced immunosuppression, the method comprising the step of administering a therapeutically or prophylactically effective amount of N6 isopentenyl adenosine to a subject in need thereof.
A method for the treatment and/or prophylaxis of blood cell depletion, the method comprising:
- providing a therapeutically effective or prophylactically effective amount of oltipraz in the form metabolite 3;
- and
- administering same to a subject in need thereof.
Dependencies are inferred from the claim text.