USP47 inhibtors and methods to induce apoptosis
AssigneeNew York University
InventorsMichele Pagano, Jeffrey R. Skaar, Angelo Peschiaroli, N. Valerio Dorrello
Life of this patent
Estimating the term…
Abstract
The present invention relates to USP47 (ubiquitin specific protease 47) inhibitors and methods for inducing apoptosis or cell death in a target cell. In certain embodiments, the invention relates to methods and kits to screen for related agents that induce apoptosis. Additionally, the invention relates to assays for screening compounds capable of acting as USP47 inhibitors.
Claims12
A method of inducing apoptosis or cell death in a target cell comprising contacting the target cell with an effective amount of an inhibitor of ubiquitin specific protease 47 (USP47), wherein the inhibitor of USP47 is a siRNA comprising SEQ ID NO:16 or SEQ ID NO:17.
A method of killing a target cell comprising contacting the target cell with an effective amount of an inhibitor of ubiquitin specific protease 47 (USP47), wherein the inhibitor of USP47 is a siRNA comprising SEQ ID NO:16 or SEQ ID NO:17.
A method of treating cancer in a subject suffering from cancer comprising administering to the subject an effective amount of a ubiquitin specific protease 47 (USP47) inhibitor, wherein the USP47 inhibitor is a siRNA comprising SEQ ID NO:16 or SEQ ID NO:17.
A method of inducing apoptosis or cell death in a target cell of a mammal which comprises contacting said target cell with an effective amount of an inhibitor of ubiquitin specific protease 47 (USP47), wherein the inhibitor of USP47 is a siRNA comprising SEQ ID NO:16 or SEQ ID NO:17.
An inhibitor of ubiquitin specific protease 47 (USP47) comprising SEQ ID NO:16 or SEQ ID NO:17.
Dependencies are inferred from the claim text.