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US 8,076,304 B2Granted
Methods and compositions for the diagnosis and treatment of cyclin A-1 associated conditions
AssigneeThe Regents of the University of Colorado
InventorsHeide L. Ford, Ricardo D. Coletta, Arthur R. Pardee, Justin Lamb
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Abstract
The present invention relates to compositions and methods for cancer therapeutics. In particular, the present invention provides compositions and methods for inhibiting cancer metastasis by inhibiting cyclin A1.
Claims2
A method for reducing cyclin A1 mRNA level in a subject, comprising
- a) providing:
- i) a subject with one or more signs or symptoms of carcinoma;
- and
- ii) a preparation comprising Six1 siRNA,
- b) administering said preparation comprising said Six1 siRNA to said subject to produce a treated subject, wherein said administering is under conditions such that the amount of cyclin A1 mRNA is reduced in said treated subject, and
- c) measuring a reduced level of cyclin A1 mRNA in said treated subject.
3 more elements
Dependencies are inferred from the claim text.