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US 8,076,300 B2Granted
FGF2-binding peptides and uses thereof
AssigneeTecnogen S.p.A.
InventorsMarco Presta, Maura Camozzi, Marco Rusnati, Maurizio Colombo, Domenico Mastroianni
Life of this patent
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Abstract
FGF2-binding peptides are here described, which have been designed starting from the N-terminal region of PTX3, in particular spanning the PTX3(82-11O) region. Synthetic peptides related to this sequence are able to bind FGF2 and to inhibit its pro-angiogenic activity in vitro and in vivo with no anticipated impact on innate immunity.
Claims4
An FGF-2 binding peptide wherein the peptide consists of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, and SEQ ID NO:
- 10 or a pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.