Cyclic hexadepsipeptides, processes for their production and their use as pharmaceuticals

An isolated compound of Formula I:

• wherein,
• R1, R2 and R3 are each independently selected from H, R8 and C(O)R9;
• R4 and R5 are each independently selected from H, C1-6alkyl, C1-6alkenyl, and C1-6alkynyl;
• R6 and R7 are each independently selected from H, R10 and C(O)R11;
• R8 and R10 are each independently selected form C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C3-10cycloalkyl, and C3-10heterocycloalkyl;
• R9 and R11 are each independently selected from H, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C3-10cycloalkyl, C3-10heterocycloalkyl, C6-10aryl, and C5-10heteroaryl, or C(O)R9 and C(O)R11 may independently be a C-coupled amino acid;
• wherein, when any of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 comprises an alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl group, then the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl group is optionally substituted with substituents selected from the group consisting of acyl, amino, acylamino, acyloxy, carboalkoxy, carboxy, carboxyamido, cyano, halo, hydroxyl, nitro, thio, C1-6alkyl, C2-7alkenyl, C2-7alkynyl, C3-10cycloalkyl, C3-10heterocycloalkyl, C6-10aryl, C5-10heteroaryl, alkoxy, aryloxy, sulfinyl, sulfonyl, oxo, guanidino and formyl;
• or an ether, an ester, an N-alkylated or N-acylated derivative, or a pharmaceutically acceptable salt thereof.