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US 8,076,116 B2Granted
Nucleic acids encoding class II human histone deacetylases, and uses related thereto
AssigneePresident and Fellows of Harvard College
InventorsChristina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber
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Abstract
The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
Claims17
An isolated nucleic acid comprising a nucleic acid sequence encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:
- 2.
An expression vector comprising the nucleic acid sequence as set forth in SEQ ID NO:
- 1, or a nucleic acid sequence encoding a polypeptide having the amino acid sequence as forth in SEQ ID NO:
- 2 and having one or more silent mutations compared with the sequence of SEQ ID NO:
- 1.
An expression vector having an insert consisting of the nucleic acid sequence as set forth in SEQ ID NO:
- 1, or a nucleic acid sequence encoding a polypeptide having the amino acid sequence as forth in SEQ ID NO:
- 2 and having one or more silent mutations compared with the sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.