Imatinib immunoassay
AssigneeSaladax Biomedical Inc.
InventorsSalvatore J. Salamone, Jodi Blake Courtney, Alexander Volkov
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Abstract
Novel conjugates and immunogens derived from imatinib and monoclonal antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of imatinib or its pharmacologically active salts in biological fluids.
Claims7
An immunoassay for detecting imatinib and its pharmacologically active salts in a sample comprising providing a mixture of a sample, an antibody selectively reactive with imatinib and its pharmacologically active salts and a conjugate of a carrier containing a polymer having either a reactive thiol or amino group with a compound of the formula:
- or its pharmacologically active salts
- wherein Y is an organic spacing group;
- X is a terminal functional group capable of binding to said carrier through said amino or thiol group and;
- p is an integer from 0 to 1;
- causing the imatinib and its pharmacologically active salts in the sample and said conjugate to bind with said antibody and thereafter measuring the amount of said conjugate in said mixture which is bound or unbound to said antibody whereby the presence of imatinib or its pharmacologically active salts in the sample can be determined.
Dependencies are inferred from the claim text.