Methods of modulating the activity of TANGO332

A method for modulating an activity of a TANGO 332 protein, the method comprising contacting the protein or a cell expressing the protein with an antibody which selectively binds to a polypeptide selected from the group consisting of:

• a) a fragment of a polypeptide having the amino acid sequence of any of SEQ ID NO:
• 61, SEQ ID NO:
• 63, and the amino acid sequence encoded by the cDNA clone deposited with ATCC® as Accession number PTA-151, wherein the fragment comprises at least 200 contiguous amino acid residues of any of SEQ ID NO:
• 61, SEQ ID NO:
• 63, and the amino acid sequence encoded by the cDNA clone, wherein the activity of the fragment to be modulated is to:
• i) bind to hyaluronic acid;
• or
• ii) bind to extracellular matrix;
• b) a polypeptide having an amino acid sequence that is at least 95% identical to any of SEQ ID NO:
• 61, SEQ ID NO:
• 63, and the amino acid sequence encoded by the cDNA clone deposited with ATCC® as Accession number PTA-151, wherein the activity of the polypeptide to be modulated is to:
• i) bind to hyaluronic acid;
• or
• ii) bind to extracellular matrix;
• and
• c) a polypeptide which is encoded by a nucleic acid molecule having a nucleotide sequence which is at least 95% identical to any of SEQ ID NO:
• 59, SEQ ID NO:
• 60, and the nucleotide sequence of the cDNA clone deposited with ATCC® as Accession number PTA-151, wherein the activity of the polypeptide to be modulated is to:
• i) bind to hyaluronic acid;
• or
• ii) bind to extracellular matrix;
• at a sufficient concentration to modulate an activity of the TANGO 332 protein.