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US 8,076,061 B2Granted
Method and composition for cancer diagnosis and treatment
AssigneeAscentGene, Inc.
InventorHui Ge
Life of this patent
Estimating the term…
Abstract
Methods and compositions for inhibiting the onset of cancer, and cancer diagnosis and treatment are provided. The treatment method comprises inhibiting the level or function of transcriptional positive factor 4 (PC4). Also provided are methods of screening for cancer inhibition agents based on inhibition of PC4 expression or function.
Claims10
A method of classifying a candidate compound as a potential anti-cancer agent comprising:
- providing a mixture containing PC4 bound to dsDNA;
- contacting said mixture with a candidate compound;
- and classifying a candidate compound that shows binding to PC4 as a potential anti-cancer agent.
A method of classifying a candidate compound as a potential anti-cancer agent comprising:
- providing a mixture containing PC4 comprising a PC4 domain that contains amino acids 16-30 (SEQ ID NO:13) or amino acids 26-40 (SEQ ID NO:11) bound to dsDNA;
- contacting said mixture with a candidate compound;
- and classifying a candidate compound that decreases binding of PC4 to dsDNA as a potential anti-cancer agent.
Dependencies are inferred from the claim text.