Adjuvant capable of specifically activating the adaptive immune response
AssigneeDuke University
InventorsSalvatore V. Pizzo, Justin P. Hart, James B. McLachlan, Herman F. Staats, Soman N. Abraham
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Abstract
A composition for eliciting an immune response to an immunogen comprises an immunogen in combination with a mast cell membrane activator such as compound 48/80. Any suitable immunogen may be employed, such as an antibody-inducing determinant, a lipid, a peptide (e.g., an antibody-inducing peptide), a carbohydrate, an immunogen derived from a virus or cancer cell, etc. Methods of use are also described.
Claims18
A method of inducing an immune response comprising concurrently administering an immunogen and compound 48/80 to a subject in an amount effective to produce an immune response therein, wherein said compound 48/80 is administered in an adjuvant-effective amount and wherein said immunogen and said compound 48/80 are administered simultaneously in a common pharmaceutical carrier.
A method of enhancing a protective immune response to an immunogen, comprising concurrently administering the immunogen and compound 48/80 to a subject in an amount effective to enhance a protective immune response relative to an immune response produced by administering the immunogen in the absence of compound 48/80, wherein said compound 48/80 is administered in an adjuvant-effective amount and wherein said immunogen and said compound 48/80 are administered simultaneously in a common pharmaceutical carrier.
A method of providing adjuvant activity to an immunogen, comprising concurrently administering the immunogen and compound 48/80 to a subject in an amount effective to produce a protective immune response, wherein said compound 48/80 is administered in an adjuvant-effective amount and wherein said immunogen and said compound 48/80 are administered simultaneously in a common pharmaceutical carrier.
Dependencies are inferred from the claim text.