Method of co-infusing a deoxygenated hemoglobin containing blood substitute and inorganic nitrite
AssigneesMontana State University - Bozeman, Duke University
InventorsJonathan S. Stamler, David J. Singel
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Abstract
Contrary to current opinion that nitrite in general oxidizes hemoglobin with elimination of active nitric oxide, deoxygenated hemoglobin reacts with low concentration inorganic nitrite to produce very stable iron nitrosyl hemoglobin which on delivery into the body is converted to a hemoglobin capable of nitric oxide delivery and provides vasodilator and antiplatelet activity. This provides basis for ameliorated risk blood product transfusions.
Claims7
A method of blood product transfusion into a human patient in need of a blood product transfusion, comprising the steps of co-administering a deoxygenated hemoglobin containing blood substitute and inorganic nitrite into the patient via infusion, wherein the inorganic nitrite is infused at a rate of 0.01 to 10 micromoles per minute, and the deoxygenated hemoglobin containing blood substitute is infused at a rate of 1 to 1000 cubic centimeters per hour.
Dependencies are inferred from the claim text.