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US 8,075,914 B2Granted
Method and formulation for treating resistance to antihypertensives and related conditions
AssigneeNeurim Pharmaceuticals (1991) Ltd.
InventorsNava Zisapel, Moshe Laudon
Life of this patent
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Abstract
A method for the prevention or treatment of symptoms of hypertension in a patient who is resistant to antihypertensive effects of an antihypertensive compound administered in the absence of melatonin comprises administering to said patient melatonin in an amount effective to ameliorate or prevent symptoms of hypertension in said patient.
Claims9
A pharmaceutical formulation which comprises:
- melatonin in an amount effective to ameliorate or prevent symptoms of hypertension developing in a patient who is resistant to antihypertensive effects of an anti-hypertensive compound administered in the absence of melatonin;
- at least one antihypertensive compound in an amount effective to exert an antihypertensive effect in presence of melatonin in a patient in need of such treatment;
- and
- at least one carrier, diluent or adjuvant.
1 more element
A pharmaceutical formulation which comprises:
- melatonin in an amount effective to ameliorate or prevent symptoms of hypertension developing in a patient who is resistant to antihypertensive effects of an anti-hypertensive compound administered in the absence of melatonin;
- at least one antihypertensive compound in an amount effective to exert an antihypertensive effect in presence of melatonin in a patient in need of such treatment;
- and
- at least one carrier, diluent or adjuvant,
- wherein the at least one antihypertensive compound comprises Diltiazem, Captopril, Atenolol, Benazepril, Enalapril, Valsaartan, Metoprolol, Terazosin, Prazosin, Minoxidil, Clonidine, or Ramipril, or pharmaceutically acceptable salts thereof.
2 more elements
Dependencies are inferred from the claim text.