High aspect ratio template and method for producing same for central and peripheral nerve repair

A method for manufacturing a biocompatible neurological platform comprising:

• immersing a matrix into a first solution, the matrix comprising a first polymer surrounding a plurality of second polymer members arranged in a desired distribution pattern within the first polymer with each of the plurality of second polymer members having a predetermined length, cross-sectional area and cross-sectional shape, the first polymer being soluble in the first solution, the plurality of second polymer members being soluble in a second solution incorporating acetonitrile and insoluble in the first solution wherein the first solution dissolves the surrounding first polymer;
• immersing the plurality of members in a third solution in which the plurality of members are insoluble, the third solution forming a biocompatible matrix surrounding the plurality of members;
• centrifuging the plurality of members immersed in the third solution;
• and
• immersing the plurality of members and surrounding biocompatible matrix in the second solution to thereby dissolve the plurality of members and create an array of pores disposed in the biocompatible matrix, wherein the pores are defined by adjacent hollow chambers comprising walls of less than about 200 micrometer thickness,
• whereby the biocompatible neurological platform is formed and comprises:
• a scaffold comprising a biocompatible material having first and second ends and a predetermined length;
• the array of pores disposed in the scaffold and extending from the first end to the second end, wherein the pores are defined by adjacent hollow chambers comprising walls of less than about 200 micrometer thickness;
• and
• a reservoir disposed in the scaffold adapted for the time-release deployment of at least one neurotrophic agent.