US 8,075,888 B2 · Methods of treatment using antibodies to IL-17 homologous polypeptides

Abstract

The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.

Claims8

Dependent claims

A method of treating a degenerative cartilaginous disorder associated with the polypeptide of SEQ ID NO:3, comprising administering a therapeutically effective amount of an antagonist antibody or fragment thereof to said polypeptide wherein the antibody or fragment binds to

(a) the polypeptide of SEQ ID NO:3;
(b) the polypeptide of SEQ ID NO:3 lacking its associated signal peptide;
or
(c) the polypeptide encoded by the cDNA clone deposited as ATCC deposit number 203552.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

12/788,129Filed 26 May 2010 · continuation

Priority

15 May 1998

Published

US 2011/0038868 A117 Feb 2011

Granted

13 Dec 2011

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

C07K 14/47
From vertebrates: from mammals
A61P 19/00
Drugs for skeletal disorders
A61P 19/02
Drugs for skeletal disorders: for joint disorders, e.g. arthritis, arthrosis
C07K 14/52
From animals; from humans: cytokines; Lymphokines; Interferons

Family

Application60/085,579Us provisional application · filed 15 May 1998

Application60/113,621Us provisional application · filed 23 Dec 1998

Application09/311,832Parent of this continuation · filed 14 May 1999

Application09/854,280Parent of this continuation · filed 10 May 2001

Application11/436,554Parent of this continuation · filed 19 May 2006

Application12/188,054Parent of this continuation · filed 7 Aug 2008

US 2011/0038868 A1Pre-grant publication · published 17 Feb 2011

US 7,749,500 B2Parent of this continuation

US 7,115,398 B2Parent of this continuation

US 2002/0052027 A1Published application

US 2006/0205038 A1Published application

US 2009/0022725 A1Published application

US 8,075,888 B2This patent

From the US filing history. Foreign family members aren’t listed.

Methods of treatment using antibodies to IL-17 homologous polypeptides

Life of this patent

Methods of treatment using antibodies to IL-17 homologous polypeptides

Life of this patent

Abstract

Claims8