Method of treatment using an anti-IL-B50 antibody
AssigneeSchering Corporation
InventorsPedro A. Reche-Gallardo, Vassili Soumelis, Yong-Jun Liu, Rene de Waal Malefyt, J. Fernando Bazan, Robert A. Kastelein
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Abstract
Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
Claims4
A method for treating allergic disease comprising administering to a patient in need thereof an antagonistic antibody or a fragment thereof that specifically binds to a polypeptide consisting of the amino acid sequence set forth in SEQ ID NO:6 in an amount sufficient to inhibit an activity selected from the group consisting of:
- i. dendritic cell production of TARC, PARC or MDC;
- and
- ii. up-regulation of a co-stimulatory or adhesion molecule on a dendritic cell, wherein said molecule is selected from the group consisting of HLA-DR, CD40, CD80, CD86, CD11a, CD18 and CD83,
- wherein the allergic disease is thereby treated.
Dependencies are inferred from the claim text.