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US 8,075,873 B2Granted
Method of preparing dry powder inhalation compositions
AssigneeNorton Healthcare Limited
InventorXian-Ming Zeng
Life of this patent
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Abstract
The invention provides a method of preparing a dry powder inhalation composition comprising a pharmaceutically acceptable particulate carrier, a first particulate inhalant medicament and a second particulate inhalant medicament. Also provided are dry powder compositions and methods of using them with a dry powder inhalation device.
Claims23
A dry powder inhalation composition prepared by a process comprising the steps of:
- (a) mixing an inert particulate carrier with a first portion of a first particulate inhalant medicament comprising an anti-inflammatory steroid to form a first mixture, wherein said particulate carrier has a volume median diameter (VMD) of from about 50 to about 250 μm, wherein the first portion of the first particulate inhalant medicament is sufficient to create a monolayer of the first particulate inhalant medicament on the particulate carrier;
- (b) mixing said first mixture with a second particulate inhalant medicament comprising a bronchodilator to form a second mixture;
- and
- (c) mixing said second mixture with a second portion of the first particulate inhalant medicament to form a dry powder inhalation composition,
- wherein, in the dry powder inhalation composition from step (c), the ratio by weight of the second particulate inhalant medicament to the carrier is less than the ratio by weight of the first particulate inhalant medicament to the carrier, and wherein the dry powder inhalation composition consists of said particulate carrier, said first particulate inhalant medicament and said second particulate inhalant medicament.
2 more elements
A method of preparing a dry powder inhalation composition comprising the steps of:
- (a) mixing an inert particulate carrier with a first portion of a first particulate inhalant medicament to form a first mixture, wherein said particulate carrier has a volume median diameter (VMD) of from about 50 to about 250 μm, wherein the first portion of the first particulate inhalant medicament is sufficient to create a monolayer of the first particulate inhalant medicament on the particulate carrier;
- (b) mixing said first mixture with a second particulate inhalant medicament to form a second mixture;
- and
- (c) mixing said second mixture with a second portion of the first particulate inhalant medicament to form a dry powder inhalation composition,
- wherein, in the dry powder inhalation composition from step (c), the ratio by weight of the second particulate inhalant medicament to the carrier is less than the ratio by weight of the first particulate inhalant medicament to the carrier.
2 more elements
A method of preparing a dry powder inhalation composition comprising the steps of:
- (a) mixing an inert particulate carrier with a first portion of a first particulate inhalant medicament comprising an anti-inflammatory steroid to form a first mixture, wherein said particulate carrier has a volume median diameter (VMD) of from about 50 to about 250 μm, wherein the first portion of the first particulate inhalant medicament is sufficient to create a monolayer of the first particulate inhalant medicament on the particulate carrier;
- (b) mixing said first mixture with a second particulate inhalant medicament comprising a bronchodilator to form a second mixture;
- and
- (c) mixing said second mixture with a second portion of the first particulate inhalant medicament to form a dry powder inhalation composition,
- wherein, in the dry powder inhalation composition from step (c), the ratio by weight of the second particulate inhalant medicament to the carrier is less than the ratio by weight of the first particulate inhalant medicament to the carrier.
2 more elements
Dependencies are inferred from the claim text.