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AssigneeWisconsin Alumni Research Foundation
InventorsWilliam L. Murphy, Jae-Sam Lee, Mark D. Markel, Ben K. Graf
Estimating the term…
Controlled release of biopharmaceutical growth factors from a hydroxyapatite coating on a bioresorbable interference screw used in cruciate ligament reconstruction surgery on a human. Biologically active scaffolds, such as interference bone screws used for ligament fixation, made by growing calcium phosphate-based hydroxyapatite coatings on bioresorbable poly(α-hydroxy ester) scaffolds that provide controlled mineral dissolution and controlled release of bone morphogenetic protein-2. The biologically active scaffold provides improved bioavailability of BMP-2 growth factor that in turn provides enhanced graft-bone healing in the tibial bone tunnel. The coating method uses surface hydrolysis and modified simulated body fluid incubation which does not require solvent or heat and is conducted at room temperature.
An implantable scaffold comprising a bioresorbable substrate, the implantable scaffold made by a method comprising:
An interference screw comprising a bioresorbable substrate, the interference screw made by a method comprising:
An orthopedic implant for controlled delivery of one or more active biopharmaceutical growth factors comprising:
A method of growing hydroxyapatite on a bioresorbable substrate, the hydroxyapatite having one or more active biopharmaceutical growth factors chemically bonded therein, comprising:
An orthopedic implant for controlled delivery of growth factor comprising:
Dependencies are inferred from the claim text.