Pre-filled syringe with anti-tamper cap

A tamper-evident syringe comprising:

• a tubular body with a longitudinal axis having a piston able to slide inside the tubular body and arranged in an initial position defining, with the tubular body, a reservoir for containing a liquid, the tubular body having a circumference;
• a rod for actuating the piston and extending beyond a proximal end of the body;
• a tip at a distal end of the body to accept a needle;
• a flange defined at the proximal end of the body;
• and
• tamper-evident means securable about an entire circumference of the flange, the tamper-evident means comprising:
• two separate pieces dimensioned for receiving the flange and an entire circumferential portion of the tubular body therebetween when the two separate pieces are permanently secured to each other about the longitudinal axis by at least one locking mechanism, so that the flange is maintained between the two pieces;
• a cover plate formed from the two separate pieces configured to cover the at least one locking mechanism when the two separate pieces are permanently secured to each other to prevent access to the locking mechanism;
• a lower platform formed from the two separate pieces defining a first opening having a first size and substantially circular shape and configured to receive the circumference of the tubular body, each of the two separate pieces forming a portion of the first opening, wherein each portion of the first opening is smaller than the flange;
• and
• an upper platform formed from the two separate pieces defining a second opening having a second size and substantially circular shape, each of the two separate pieces forming a portion of the second opening, wherein each portion of the second opening is smaller than the flange,
• wherein the first opening has a size and shape corresponding to the external dimensions of the body and the second opening has a size and shape to permit free movement of the rod therein and to prevent removal of the piston from the body.