Biopsy devices with universal probe

A method of combining a biopsy probe with a holster to provide a biopsy device, wherein the biopsy probe comprises a needle, a cutter, and a body portion, wherein the needle has a tissue piercing tip and a tissue receiving aperture proximal to the tip, wherein the cutter is operable to translate relative to the needle to sever tissue protruding through the aperture, wherein the needle is rotatable relative to the body portion, wherein the holster comprises a locking feature configured to engage a portion of the probe, wherein the locking feature is configured to prevent the needle from rotating relative to the body portion upon coupling of the probe with the holster, and wherein the locking feature is fixed relative to the holster, the method comprising:

• (a) adjusting the angular orientation of the tissue receiving aperture by rotating the needle about an axis defined by the needle to reach a selected angular orientation;
• and
• (b) coupling the probe with the holster to lock the selected angular orientation with the locking feature, wherein the locking feature prevents any rotation of the needle for the entire duration of the biopsy probe being coupled with the holster.