US 8,074,649 B2Granted

Endotracheal tube with feature for delivering aerosolized medication

AssigneeAeon Research and Technology, Inc.

InventorsSunil Kumar Dhuper, Sarita Dhuper

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Abstract

Current methods of drug administration to the lungs are inefficient. ‘Endotracheal Tube with Aerosol Delivery Apparatus III’ is specifically designed for uniform intrapulmonary delivery of aerosolized medication in patients on mechanical ventilation. As opposed to the current methods of drug delivery where aerosol particles are generated at the proximal end of the ETT, with majority of the particles adhering to the endotracheal tube during delivery, this invention bypasses the endotracheal tube by generating aerosol particles at its distal end. The invention consists of two coaxial hollow tubes fused to each other. The inner coaxial tube and/or one or more secondary cannulation(s) in the wall of the outer coaxial tube terminate at proximal and as MDI adapters and at the distal tip as a single or multiple micrometric orifices. The device generates one or more aerosol plumes with different geometries, velocities and orientations made possible by variations in the ID, shape, trajectory and orientation of secondary cannulation(s) and the distal orifice(s) to ensure effective aerosol delivery to respiratory system.

Claims14

Dependent claims

An aerosol delivery device comprising:

a ventilator connector that is configured to mate with a conduit that leads to a ventilator for permitting inhalation and exhalation by a patient, the ventilator connector having a hollow first leg and a hollow second leg that is formed at an angle relative to the first leg, the first leg including an adapter that is defined by a hollow body that defines a lumen that is axially aligned with a lumen defined by the second leg;
a medicament dispenser containing medication in aerosol form that is selectively delivered through a distal orifice of a nozzle of the dispenser;
a medicament dispenser connector that is configured to be sealingly mated to the medicament dispenser and in communication with an endrotracheal tube, the medicament dispenser connector including a proximal hollow body portion that is configured to sealingly mate with a dispenser element of the medicament dispenser so as to fluidly link the two together;
an elongated cannula portion extending from the proximal hollow body portion of the medicament dispenser connector, the cannula portion comprising a tubular structure that is defined by a main lumen and inner and outer walls;
and
a plurality of secondary orifices that are formed in proximal and distal segments of the tubular structure of the cannula portion, said secondary orifices being open along both the inner wall and the outer wall of the tubular structure and being in direct fluid communication with the main lumen,
wherein the cannula portion has a plurality of secondary medication delivery conduits each of which has a lumen and an orifice that are fluidly connected to the medicament dispenser connector, said secondary medication delivery conduits being formed in the cannula portion between the inner and outer walls of the cannula portion and extending at least along a length thereof such that each lumen of the secondary medication delivery conduit is fluidly separated from the main lumen of the cannula portion,
wherein in a dispensing mode, aerosol particles generated by the medicament dispenser are separately delivered through the main lumen of the cannula portion, as well as through the lumens of the secondary medication delivery conduits and through the secondary orifices into the endotracheal tube and into lungs of the patient such that a central aerosol plume is generated from the main lumen of the cannula portion and peripheral aerosol plumes are generated from the lumens of the secondary medication delivery conduits.

5 more elements

A medication delivery system comprising:

an MDI device for delivering aerosolized medication, the MDI device having a nozzle;
an MDI adapter that is constructed to receive and mate with the nozzle of the MDI device, the MDI adapter including;
a first elongated hollow tube that includes a main lumen that extends along a longitudinal length thereof, the hollow tube being defined by inner and outer walls;
and
a plurality of secondary medication delivery conduits each of which has a lumen that extends a length of the hollow tube and is formed internally within the tubular wall between the inner and outer walls, the lumen of the second medication delivery conduits being fluidly separated from the main lumen, wherein at least some of the secondary medication delivery conduits include proximal orifices at a proximal end of the hollow tube that are fluidly connected to the MDI device;
wherein at least one secondary medication delivery conduit has an upper portion that is angled and extends through the elongated hollow tube and terminates at its proximal end in an adapter that is freely accessible along an exterior of the hollow tube, the angled portion being formed of a semi-flexible material;
wherein the MDI adapter is configured to be fluidly mated with a ventilator adapter that is configured to connect to the ventilator device and be positioned so that it is axially aligned and in fluid communication with the proximal orifices of the secondary medication delivery conduits, the MDI adapter having an inlet port that is adapted to mate with the MDI device and is configured to be received within a central bore of an endotracheal tube and isolation of the secondary medication delivery conduits permits aerosolized medication to be delivered to the patient without interference from the delivery of air through the endotracheal bore.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/197,396Filed 18 Jul 2002
Published: US 2004/0011364 A122 Jan 2004
Granted: 13 Dec 2011
Term ends: Not estimatedThe source records don’t support an estimate.

Classification5 codes

A61M 16/04
Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators ; Tracheal tubes: tracheal tubes
A61M 16/0404
Special features for tracheal tubes not otherwise provided for: with means for selective or partial lung respiration
A61M 16/0484
With incorporated means for delivering or removing fluids: at the distal end
A61M 15/009
Inhalators: using medicine packages with incorporated spraying means, e.g. aerosol cans